Are you aware during a PNES seizure?

Consciousness and awareness during PNES - Many patients with PNES feel "distant" from their environment during the episode, although they are not completely unconscious, similar to an "out of body" experience ; -Many patients are described as "going blank" or "absent" during a PNES episode.

Are psychogenic non epileptic seizures real?

"PNES is not caused by abnormal brain electrical activity." PNES resemble, mimic or can appear outwardly like epileptic seizures, but their cause is psychological. PNES in most cases come from a psychological conflict or accompany an underlying psychiatric disorder . There is no known organic or physical cause for PNES.

How do you respond to PNES?

But there are things you can do to help: Stay with the person and keep calm. Move the person to a quiet place. Ask what the person needs. Speak to the person in short, simple sentences. Be predictable, and avoid surprises. Help the person focus. ... Help slow the person's breathing. ... Know what to say.

How long can a PNES episode last?

Finally, PNES usually has a more prolonged course than an epileptic episode (epileptic seizures usually last 2–3 minutes, while PNES can last several minutes to hours ).

Are eyes open during PNES?

Among patients with PNES, 50 of the 52 patients con- sistently closed their eyes during their habitual seizures (video E-1 on the Neurology Web site at www. neurology. org). Most of them closed their eyes for the entire duration of the seizure and a few closed their eyes forcefully with facial frowning.

What percentage of PNES patients have epilepsy?

The proportion of patients with psychogenic nonepileptic seizures (PNES) who also have epilepsy has been reported to vary from 10% to over 50% .

Can PNES cause confusion?

Unless they deliberately feign postictal confusion , PNES patients recover their attentiveness and motor function immediately after the cessation of the movements. Most patients have no lingering confusion, headache, retrograde amnesia, or hemiparesis. In short, postictal symptoms do not follow most PNES.

What happens in the brain during PNES?

These findings indicate that the brains of patients with PNES can exhibit a paroxysmal attack of emotion, movement, and behavior due to abnormal interactions between areas involving emotional and cognitive control, sensorimotor activity, and involuntary motor activity.

Psychogenic Nonepileptic Seizures (2024)

Continuing Education Activity

Pseudoseizures, psychogenic seizures, and hysterical seizures are older terms used to describe events that clinically resemble epileptic seizures but occur without the excessive synchronous cortical electroencephalographic activity that defines epileptic seizures. Commonly used current terms for this phenomenon are psychogenic nonepileptic spells or seizures (PNES), psychogenic nonepileptic episodes (PNEE), or psychogenic nonepileptic attacks. These terms reinforce the idea that the events are not epileptic seizures and are of psychiatric origin. This activity reviews how to evaluate psychogenic nonepileptic spells properly and outlines further steps that should be taken when seizure-like presentations are observed or reported. This activity highlights the role of the interprofessional team in caring for patients with psychogenic nonepileptic spells.

Objectives:

Describe patient history clues that might lead to consideration of psychogenic nonepileptic spells.
Outline how a definitive diagnosis of psychogenic nonepileptic spells may be made.
Explain how to manage a patient affected by psychogenic nonepileptic spells properly.
Identify interprofessional team strategies for improving care coordination and communication to enhance outcomes for patients affected by psychogenic nonepileptic spells.

Access free multiple choice questions on this topic.

Introduction

Pseudoseizure is an older term for events that appear to be epileptic seizures but, in fact, do not represent the manifestation of abnormal excessive synchronous cortical activity, which defines epileptic seizures. They are not a variation of epilepsy but are of psychiatric origin. Other terms used in the past include hysterical seizures, psychogenic seizures, and others. The most standard current terminology is psychogenic nonepilepticseizures (PNES). Some advocate other terms such as psychogenic functional spells or psychogenic nonepileptic events, spells, or attacks. These terms reinforce the idea that the events are not epileptic seizures.[1][2][3][4][5]A retrospectivereview of a small number of patients over a number of years revealed that dozens of different diagnostic terms were used to describe these events.[5]Thoughestablished in use, the term pseudoseizure and others should be regarded as jargon, and the use of psychogenic nonepileptic seizures (or alternatively, spells) (PNES) is encouraged for clarity.

Distinguishing PNES from epileptic seizures may be difficult at the bedside even to experienced observers. In theory, almost any recurrent behavior may represent epileptic seizures. The evolution of epilepsy monitoring units and the ability to utilize simultaneous video and EEG recordings may be a key to diagnosis.[6][7]Video electroencephalography (video-EEG) of a typical event showing the absence of epileptiform activity during the spell with acompatible history is regarded as the gold standard for diagnosis.[8]Diagnostic delay of years with psychogenic nonepileptic seizures is common.[9]

Treatment of PNES may be difficult, but it is clear that anti-epileptic drugs (AEDs) are of no benefit. In addition to unnecessary costs and the potential side effects of AEDs for these patients, life-threatening side effects such as respiratory depression may occur if psychogenic nonepileptic status epilepticus is treated with large dosages of benzodiazepines.[10]

Etiology

The most common psychiatric mechanism is thought to be a conversion disorder. A conversion disorder, by definition, implies that the individual is not aware and is not consciously feigning events. A history of sexual or physical abuse is a risk factor for the development of PNES. The majority of patients are adult women. A disproportionate number of patients with PNES have training in health care careers. How these risk factors summate to produce spells is unclear. Other psychiatric comorbidities may include depression, anxiety disorders, PTSD, or personality disorders.

Malingering or factitious disorder is thought to be less common as a cause of PNES but might be suspected when there is clear, immediate secondary gain resulting in alterations in behavior.

Epidemiology

The incidence of PNES is unknown. However,inpatients admitted to epilepsy monitoring units for unusual or intractable seizures, about 20% to 40% are diagnosed with PNES rather than epileptic seizureswith extended video-EEG monitoring. In a recent study of generalized convulsive status epilepticus, 10% of patients thought to have benzodiazepine-refractory generalized convulsive status epilepticus who were given additional antiepileptic drugs after adjudicated review were found to have PNES.[11]

Pathophysiology

Some evidence from functional and structural neuroimaging studies suggests PNES may reflect alterations in sensorimotor, emotional regulation/processing, cognitive control, and integration of neural circuits.[8]

History and Physical

Psychogenic nonepileptic seizures may be difficult to distinguish from epileptic seizures. Observation of waxing and waning consciousness, out-of-phase shaking movements, pelvic thrusting, side-to-side head shaking, and eye closure during the event suggest PNES. However, at times brief episodes of sudden unresponsiveness may represent the PNES event. Sometimes, friends or family may volunteer a history of nonepileptic seizures or spells, but frequently this is lacking, and the patient has been labeled as having a seizure disorder and is being prescribed antiepileptic drugs.

Even in a busy emergency department, there is always a brief moment of observation before starting treatment. Therapy should not be blindly protocol-driven without some inspection and examination.[12] Most patients with convulsive seizures will have open eyes. Closed eyes, especially tightly closed eyes with resistance to eye-opening during an event, are inconsistent with epileptic seizures. Eye closureduringspells has consistently been found to be a reliable sign for PNES (95% and above) though occasional exceptions are observed.[13][14]

Evaluation

Again, observation is key, and clinicians should avoid any rush to unhelpful interventions or treatments.

Correct diagnosis is necessary for successful treatment. Patients with psychogenic nonepileptic spells have frequently been misdiagnosed as having epilepsy and have been prescribed multiple medications. Consultation with neurology may be helpful. Admission to a monitoring unit may be in order if the diagnosis is uncertain. Long-term video EEG monitoring is the most important diagnostic test.[22]Recently, short-term video-EEG has been found useful in the diagnosis of PNES.[10]

Laboratory testing is of limited utility. Serum prolactin levels have long been noted to increase shortly after a generalized epileptic seizure but not after PNES.Prolactin levelspeak quickly after events, and though discussed extensively in the literature, they are of limited pragmatic value. A lactic acidosis commonly follows a generalized convulsion. However, a rise in lactate levels is not specific for convulsions of epileptic origin; elevated lactate levels occurred in volunteers simulating generalized seizures.[23]Elevated creatine kinase levels after generalized convulsive status epilepticus were observed compared to patients with psychogenic nonepileptic status epilepticus and may be useful in distinguishing psychogenic status epilepticus from generalized convulsive status epilepticus.[24]

Treatment / Management

In challenging cases, admission to an epilepsy monitoring unit or similar facility with combined video-EEG monitoring may be needed to secure the diagnosis. The best treatment is not known but may consist of a combination of medicationif depression or anxiety exists and cognitive behavioral therapy. An honest and clear discussion of the patient's diagnosis is of utmost importance. In cases of conversion disorder, it is important to acknowledge that the spells are real and cause distress to the patient, family, and friends. It should be articulated that the episodes are not seizures. A respectful approach and the reassurance that supportive therapy will most likely decrease or even eliminate the frequency of spells should be outlined. If the diagnosis of PNES is secure, anti-epileptic drugs should be withdrawn.[25][26]

Differential Diagnosis

Psychogenic nonepileptic seizures are largely a diagnosis of exclusion. Any paroxysmal event may simulate a seizure or PNES such as syncope, arrhythmia, and other spells. Movement disorders or sleep disorders may be in the differential diagnosis. Once otherparoxysmal events are excluded, the distinction between epileptic seizures and PNES may remain a challenge. The differential diagnosis for PNES includes:

Absence seizures
Complex partial seizures
Vertigo
Syncope

Prognosis

The prognosis of patients with PNES is not clear. With correct identification of spells and diagnosis of PNES, treatment of any psychiatric co-morbidities and counseling may decrease the frequency of spells. Cognitive-behavioral therapy-informed psychotherapy does seem to be efficacious. Patient acceptance of the diagnosis of PNES is thought to improve outcomes.[8]

Complications

Though sometimes used to "wake up" a patient thought to be having feigned unresponsiveness or nonepileptic spells, noxious stimuli such as ammonia capsulesshould be avoided.Communication between health care professionals of observations is essential.

The recent study of drug regimens in benzodiazepine-refractory generalized convulsive status epilepticus found that 10% of the subjects entered into the study on detailed review were found to have PNES.[11] Potential complications of erroneously treating generalized status epilepticus include adverse reactions to medications. One study found that with the misdiagnosis of PNES as convulsive status epilepticus, massive doses of antiepileptic drugs were administered until impaired consciousness, or respiratory failure occurred.[12] Unneeded endotracheal intubations with iatrogenic complications have been reported.[27][28]

Deterrence and Patient Education

As discussed previously, the correct diagnosis of PNES is necessary to allow appropriate interventions. Patient and family education about the psychiatric etiology of the spells and withdrawal of antiepileptic medications is beneficial in decreasing the frequency of spells.

Pearls and Other Issues

Though the pattern of a generalized convulsive seizure typically is one of abrupt onset, brief tonic posturing followed by synchronized clonic extremity movements, alteration of consciousness, and a postictal confusion phase, exceptions do occur, particularly in patients with partial-onset seizures starting in frontal or temporal areas. At times there are unusual motor patterns with partial-onset seizures or persistent confusional states with minor motor automatisms. If permissible by hospital policies, capturing events with video or smartphones may be useful for later analysis.

Enhancing Healthcare Team Outcomes

An interprofessional team of healthcare professionals is needed for the ideal treatment of PNES. This team will include clinicians (including NPs and PAs), specialists (such as a neurologist), nursing staff, pharmacists, and mental health professionals, all collaborating across disciplinary boundaries to achieve optimal patient outcomes. Team members should be consistent in communication with the patient and family members. Neurologic evaluation and referral to appropriate psychiatric or counseling resources is an ideal course.

Review Questions

References

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: Disclosure: J. Stephen Huff declares no relevant financial relationships with ineligible companies.
: Disclosure: Najib Murr declares no relevant financial relationships with ineligible companies.